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Quick Details

  • CAS No.: 6384-92-5
  • Other Names: (R)-2-(Methylamino) succinic acid, NMDA
  • MF: C5H9NO4
  • EINECS No.: 227-012-0
  • Place of Origin: Shanghai, China (Mainland)
  • Type: Vitamins, Amino Acids and Coenzymes
  • Grade Standard: Food Grade
  • Brand Name: WASETA
  • Model Number: WASETA - NMDA
  • Purity: 98% MIN.
  • Appearance: White Crystal powder
  • Assay: 98% MIN.
  • CAS: 6384-92-5

Packaging & Delivery

Packaging Details: 1kg/aluminum foil bag; 10kg/drum or as you require
Delivery Detail: 3 working days after order confirmation

Specifications

N-Methyl-D-Aspartic Acid (NMDA)
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N-Methyl-D-Aspartic Acid (NMDA)

 

Description: 

N-Methyl-D-aspartic acid or N-Methyl-D-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors (such as those for AMPA and kainate). NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.

 

Specification:

Function:

 

N-Methyl-D-Aspartic acid (NMDA) is a water-soluble synthetic substance that is  not normally found in biological tissue. It was first synthesized in 1960s. N-Methyl-D-Aspartic acid (NMDA) is an excitotoxin(it kills nerve cells by over-exciting them);  this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term "lesion studies."  

 

Researchers apply N-Methyl-D-Aspartic acid (NMDA) to specific regions of an  (animal) subject's  brain  or spinal cord and subsequently test for the behavior of  interest,  such as operant behavior. If the behavior is compromised, it suggests  the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. 

 

However, in lower quantities N-Methyl-D-Aspartic acid (NMDA) is not neurotoxic.  

 

In  fact, normal operation of the N-Methyl-D-Aspartic acid (NMDA)  receptor allows  individuals to respond to excitatory stimuli through the interrelated functioning of N-Methyl-D-Aspartic acid (NMDA) receptors, glutamate, and dopamine. 

 

Therefore the action of glutamate specifically through N-Methyl-D-Aspartic acid  (NMDA) receptors can be investigated by injecting small quantities of N-Methyl-D-Aspartic acid (NMDA) into a certain region in the brain: for example, injection of N-Methyl-D-Aspartic acid (NMDA) in a brainstem region induces  involuntarylocomotion in cats and rats. 

 

The mechanism of stimulating N-Methyl-D-Aspartic acid (NMDA) receptor is a  specific agonist-binding to its NR2 subunits, and then a non-specific cation  channel is opened, which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. The excitatory postsynaptic potential (EPSP) produced by activation of an N-Methyl-D-Aspartic acid (NMDA) receptor  also increases  the  concentration of Ca2+ in the cell. The Ca2+ can in turn function as a second messenger in various signaling pathways.This process is modulated by a number of endogenous and exogenous compounds and play a key role in a wide range of physiological (e.g. memory) and pathological processes (e.g. excitotoxicity). 

 

It has been deemed responsible for the incredible increase of hormonal output experienced during puberty, which results in rapid muscular and sexual development. This hormonal state is most desirable for building muscle mass and even useful in enhancing every aspect of sexual performance. This newly found receptor, when powerfully activated by amino acid based ingredient called N-Methyl-D-Aspartic acid (NMDA), elicits profound  elevations of circulating anabolic hormones.There are studies showing it increases LH and test levels. N-Methyl-D-Aspartic  acid (NMDA) receptor activation also plays a role in developing many neuro-degerative disorder like Parkinsons.

 

 

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